The 2022 NCAA Division I Women’s Basketball Tournament was a single-elimination tournament of 68 teams to determine the National Collegiate Athletic Association (NCAA) Division I college basketball national champion for the 2021–22 NCAA Division I women’s basketball season. The 40th edition of the tournament began on March 16, 2022, and concluded with the championship game on April 3 at Target Center in Minneapolis, where the South Carolina Gamecocks defeated the UConn Huskies 64–49 to win their second NCAA title.

For the first time, the tournament was expanded to 68 teams, expanding from the 64-team field used from 1994 through 2021 and matching the men’s 68-team field in use since 2011.

Big South champion Longwood, Horizon champion IUPUI, and Southland champion Incarnate Word made their tournament debuts. Tennessee continued its record streak of making every edition of the tournament, while UConn extended its record streak of 14 consecutive Final Four appearances.