Former Navy and Utah State head coach Charlie Weatherbie was hired to replace Keasler in 2003. In Weatherbie’s seven seasons, ULM compiled a 31–51 record. The highlight of the Weatherbie era came in 2007, when ULM, who were 25-point underdogs heading into the game, beat Alabama, coached by Nick Saban, in Tuscaloosa 21-14 on November 16. The win marked Louisiana–Monroe’s first win over a SEC team in a dozen years (their third overall), and, as of 2020, is Nick Saban’s only regular season loss to a non-Power 5 team during his tenure at Alabama.