On March 17, 2020, Drew was hired as the head coach of Grand Canyon, replacing Dan Majerle.[16]

On March 6, 2021, Drew coached Grand Canyon to its first WAC regular-season championship in school history. A week later, the Antelopes won the WAC tournament championship as well, earning their first trip to the 2021 NCAA Division I men’s basketball tournament in the process. The pandemic-impacted tournament was held entirely in Indianapolis, where the Lopes were a 15 seed and feel to No. 2-seed Iowa at Indiana Farmers Coliseum.

Despite his team largely underachieving in 2022-23 — finishing fifth in the WAC standings after being named the preseason favorite — the Lopes went on a run in the WAC tournament, winning four games in four days to return to the NCAA tournament where they fell to Gonzaga in Denver.