As the stadium was designed first and foremost for the Minnesota Vikings, they had the fewest problems. However, the economics of 21st century professional sports meant that the Vikings owners wanted more luxury suites and better concessions. Renovations were rejected twice, with the 2001 price tag at $269 million.

The Vikings played their first game at the Metrodome in a preseason matchup against the Seattle Seahawks on August 21, 1982. Minnesota won 7-3. The first touchdown in the dome was scored by Joe Senser on an 11-yard pass from Tommy Kramer. The first regular-season game at the Metrodome was the 1982 opener on September 12, when the Vikings defeated Tampa Bay Buccaneers, 17-10. Rickey Young scored the first regular-season touchdown in the dome on a 3-yard run in the 2nd quarter. On January 9, 1983, the Vikings defeated the Atlanta Falcons, 30-24, in a 1st-round game that was the first playoff game at the Metrodome. On January 17, 1999, the Falcons defeated the Vikings in the first NFC championship game played at the dome. On December 29, 2013, the Vikings played their final game at the Metrodome, a 14-13 victory over the Detroit Lions. The team’s all-time record at the dome was 162-88 in the regular season and 6-4 in playoff games.