Arkansas–Pine Bluff has had 6 Major League Baseball Draft selections since the draft began in 1965.

Golden Lions in the Major League Baseball Draft
2002 Isiah Garner 31 Devil Rays
2009 Zachary Varnell 44 Diamondbacks
2011 Chretien Matz 44 Tigers
2014 Isias Alcantar 36 Rays
2015 Kevin Walsh 21 Phillies
2015 Byron Davis 8 Royals